The Nuts and Bolts of Drug Development Explained, Episode 4, Breaking Down Pharmacokinetics.
Pharmacokinetics, or PK, is the study of what the body does to a drug over time, how its concentration rises and falls after a dose. For pre|CISION® medicines, that story matters in two places at once: the plasma and the tumor. In this episode, our Associate Directors of Clinical Science & Translational Medicine Gezim Lahu and Ruairidh Edwards walk through the fundamentals, from the ADME journey every drug takes to the Tumor Selectivity Index (TSI), the ratio of tumor exposure to systemic exposure that sits at the heart of tumor-activated therapy.