Concentrating highly potent warheads in the tumour microenvironment

The Avacta pre|CISIONTM platform is a proprietary warhead delivery system based on a tumour-specific protease that is designed to concentrate highly potent warheads in the tumour microenvironment while sparing normal tissues.

Fibroblast activation protein-α (FAP) is an extracellular post-proline protease that is upregulated in many solid tumours in a membrane-bound form on cancer associated fibroblasts as well as tumour cells. FAP activity is also observed as a soluble protease to a low degree in plasma.

A pre|CISIONTM molecule has two key properties:

  1. It prevents the warhead from entering cells.
  2. It is specifically cleaved by FAP to release active warhead in the tumour.

The peptide moiety linker, pre|CISION™, prevents cellular entry of the warhead unless it is cleaved by FAP, thus enabling targeted delivery of the warhead to tumours.

The first of the pre|CISION molecules, AVA6000, has achieved clinical proof-of-concept.


pre|CISIONTM can be utilised in multiple drug formats:

pre|CISION peptide drug conjugate (PDC)

The warhead is linked to a peptide specifically cleaved by FAP which prevents cell entry until released by FAP in the extracellular TME. t1/2: mins to hours

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pre|CISION+ half-life optimised conjugate

The peptide-warhead conjugate is linked to the Fc region, producing a pre|CISIONTM molecule with prolonged half-life and DAR~10. t1/2: ~hours – days

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pre|CISION ADC drug conjugate (AffDC)

The peptide-warhead conjugate is linked  to a tumour antigen-targeted monoclonal antibody or Affimer®, creating a highly tumour-specific ADC. t1/2: ~days – weeks

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Discover pre|CISIONTM technology – watch the Mechanism of Action video below.

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